RT Journal Article
SR Electronic
T1 THE ABSORPTION RATES OF INSULIN, GLOBIN INSULIN AND PROTAMINE ZINC INSULIN LABELLED WITH RADIOACTIVE IODINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 352
OP 357
VO 78
IS 4
A1 L. REINER
A1 E. H. LANG
A1 JOHN W. IRVINE, JR.
A1 WENDELL PEACOCK
A1 ROBLEY D. EVANS
YR 1943
UL http://jpet.aspetjournals.org/content/78/4/352.abstract
AB Radioactive iodine has been used for labelling insulin by coupling diazotized radioactive iodoaniline to insulin. The absorption rate of radioactive insulin injected subcutaneously was compared with its absorption rate from two depot insulin preparations by measuring the decrease of radioactivity at the site of the injection. A correlation was found to exist between the differences in the absorption rate and the differences in the intensity of hypoglycemic action produced by the preparations studied. The rate of the absorption of insulin from these preparations was found to be in the following order: insulin > globin insulin (with zinc) > protamine zinc insulin.