PT  - JOURNAL ARTICLE
AU  - L. REINER
AU  - E. H. LANG
AU  - JOHN W. IRVINE, JR.
AU  - WENDELL PEACOCK
AU  - ROBLEY D. EVANS
TI  - THE ABSORPTION RATES OF INSULIN, GLOBIN INSULIN AND PROTAMINE ZINC INSULIN LABELLED WITH RADIOACTIVE IODINE
DP  - 1943 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 352--357
VI  - 78
IP  - 4
4099  - http://jpet.aspetjournals.org/content/78/4/352.short
4100  - http://jpet.aspetjournals.org/content/78/4/352.full
SO  - J Pharmacol Exp Ther1943 Aug 01; 78
AB  - Radioactive iodine has been used for labelling insulin by coupling diazotized radioactive iodoaniline to insulin. The absorption rate of radioactive insulin injected subcutaneously was compared with its absorption rate from two depot insulin preparations by measuring the decrease of radioactivity at the site of the injection. A correlation was found to exist between the differences in the absorption rate and the differences in the intensity of hypoglycemic action produced by the preparations studied. The rate of the absorption of insulin from these preparations was found to be in the following order: insulin > globin insulin (with zinc) > protamine zinc insulin.