RT Journal Article
SR Electronic
T1 A THERAPEUTIC INCOMPATIBILITY BETWEEN SULFAPYRIDINE AND QUININE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 42
OP 51
VO 74
IS 1
A1 BEN KING HARNED
A1 VERSA V. COLE
YR 1942
UL http://jpet.aspetjournals.org/content/74/1/42.abstract
AB 1. Quinine administered orally with sulfapyridine to rats increased the total amount of sulfapyridine absorbed and excreted in the urine. The maximal increase was produced by the largest dose of quinine and, using average values, amounted to 44 per cent. 2. The increase in the urinary excretion of total sulfapyridine represented principally an increase in the acetylsulfapyridine. The largest dose of quinine produced an average increase of 96 per cent in the excretion of acetylsulfapyridine. This effect was not accompanied by an increase in the volume of urine. 3. Quinine depressed the free sulfapyridine in the urine. The maximal decrease observed was 33 per cent. 4. Atabrine substituted for quinine produced no comparable effect.