RT Journal Article
SR Electronic
T1 THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 79
OP 89
VO 78
IS 1
A1 E. B. ASTWOOD
YR 1943
UL http://jpet.aspetjournals.org/content/78/1/79.abstract
AB The relative effectiveness of 106 chemical compounds in inhibiting the function of the thyroid gland was tested in young rats. When these substances were administered in the food or drinking water for a period of ten days, the degree of thyroid hyperplasia, as estimated by gross and microscopic examination, provided an estimate of their activity. Two classes of compounds were found to be active: thiourea derivatives and certain derivatives of aniline. The compounds more effective than thiourea in decreasing order of activity were : 2-thiouracil, 2-thiobarbituric acid, sym.-diethylthiourea and 5-benzal-2-thiohydantoin. The effective aniline derivatives comprised the sulfonamides, p-, m-, o-aminobenzoic acids, p-aminophenylacetic acid and p-aminoacetanilide. Thiocyanates were found to cause thyroid enlargement only in the absence of added iodide, while organic cyanides failed to influence the thyroid gland.