PT  - JOURNAL ARTICLE
AU  - VERSA V. COLE
TI  - THE EFFECT OF CALCIUM AND STRONTIUM SALTS ON THE ACTION OF SODIUM PENTOBARBITAL
DP  - 1941 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 335--342
VI  - 73
IP  - 3
4099  - http://jpet.aspetjournals.org/content/73/3/335.short
4100  - http://jpet.aspetjournals.org/content/73/3/335.full
SO  - J Pharmacol Exp Ther1941 Nov 01; 73
AB  - 1. Both calcium and strontium acetates increased the duration of sodium pentobarbital anesthesia when the salts were given in equimolecular quantities by intraperitoneal injection. 2. Calcium acetate increased the duration of sodium pentobarbital anesthesia when given by vein. Strontium acetate had very little if any effect. 3. Calcium acetate was more toxic to the rat by intraperitoneal injection than strontium acetate. 4. The greater toxicity of the calcium by intraperitoneal injection was shown to be associated with an increased hemoglobin concentration of the blood. 5. Sodium pentobarbital decreased the toxicity of strontium acetate but strontium acetate did not decrease the toxicity of sodium pentobarbital.