TY - JOUR T1 - DISTRIBUTION AND RATE OF METABOLISM OF <em>5,5</em> DIPHENYLHYDANTOIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 280 LP - 283 VL - 72 IS - 3 AU - C. H. HINE AU - F. L. KOZELKA Y1 - 1941/07/01 UR - http://jpet.aspetjournals.org/content/72/3/280.abstract N2 - Data on the relative distribution of diphenylhydantoin in rabbit tissue and the rate of its disappearance from the body are presented. The relative concentrations in the various tissues decrease in the order listed, viz., liver, brain, kidney, blood and muscle. Approximately sixteen hours are required for the drug to disappear from the body when administered intravenously in a dose of 50 mgm. per kilogram of body weight. After the repeated oral administration of relatively large daily doses, there is evidence that the drug accumulates in the tissues, particularly in the brain. ER -