RT Journal Article SR Electronic T1 A METHOD FOR DETERMINING LOSS OF PAIN SENSATION JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 74 OP 79 VO 72 IS 1 A1 D'AMOUR, FRED E. A1 SMITH, DONN L. YR 1941 UL http://jpet.aspetjournals.org/content/72/1/74.abstract AB 1. A simple, rapid method for determining the pain threshold in the rat is described. 2. The individual variation, under a variety of conditions, was found to be surprisingly small. 3. The method was applied to the determination of analgesic properties of several substances, including cobra venom. No analgesic property in the latter could be demonstrated. 4. A comparative assay of five opiates gave results in good agreement with clinical experience.