RT Journal Article
SR Electronic
T1 A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 74
OP 79
VO 72
IS 1
A1 D'AMOUR, FRED E.
A1 SMITH, DONN L.
YR 1941
UL http://jpet.aspetjournals.org/content/72/1/74.abstract
AB 1. A simple, rapid method for determining the pain threshold in the rat is described. 2. The individual variation, under a variety of conditions, was found to be surprisingly small. 3. The method was applied to the determination of analgesic properties of several substances, including cobra venom. No analgesic property in the latter could be demonstrated. 4. A comparative assay of five opiates gave results in good agreement with clinical experience.