PT  - JOURNAL ARTICLE
AU  - FRED E. D'AMOUR
AU  - DONN L. SMITH
TI  - A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
DP  - 1941 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 74--79
VI  - 72
IP  - 1
4099  - http://jpet.aspetjournals.org/content/72/1/74.short
4100  - http://jpet.aspetjournals.org/content/72/1/74.full
SO  - J Pharmacol Exp Ther1941 May 01; 72
AB  - 1. A simple, rapid method for determining the pain threshold in the rat is described. 2. The individual variation, under a variety of conditions, was found to be surprisingly small. 3. The method was applied to the determination of analgesic properties of several substances, including cobra venom. No analgesic property in the latter could be demonstrated. 4. A comparative assay of five opiates gave results in good agreement with clinical experience.