PT  - JOURNAL ARTICLE
AU  - H. J. WHITE
AU  - A. CALVIN BRATTON
AU  - J. T. LITCHFIELD, JR.
AU  - E. K. MARSHALL, JR.
TI  - THE RELATIONSHIP BETWEEN THE IN VITRO AND THE IN VIVO ACTIVITY OF SULFONAMIDE COMPOUNDS
DP  - 1941 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 112--122
VI  - 72
IP  - 1
4099  - http://jpet.aspetjournals.org/content/72/1/112.short
4100  - http://jpet.aspetjournals.org/content/72/1/112.full
SO  - J Pharmacol Exp Ther1941 May 01; 72
AB  - A qualitative comparison of the in vitro and in vivo activity on β-hemo1ytic streptococcus of 126 compounds consisting of sulfanilamide derivatives, sulfonamides, suifones, sulfoxides, sulfides and certain miscellaneous compounds has been made. It has been shown that no compound is active in vivo unless it is active in vitro or can be decomposed in the animal body to a compound which would be active in vitro, and that compounds can be active in vitro but inactive in vivo.