RT Journal Article
SR Electronic
T1 THE EFFECTS OF SODIUM DIPHENYL HYDANTOINATE (DILANTIN) ON VITAMIN C LEVEL IN TISSUES AND VITAMIN C EXCRETION IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 268
OP 272
VO 71
IS 3
A1 MILES E. DRAKE
A1 CHARLES M. GRUBER
A1 VICTOR G. HAURY
YR 1941
UL http://jpet.aspetjournals.org/content/71/3/268.abstract
AB 1. Sodium diphenyl hydantoinate (Dilantin) given orally to albino rats causes an increase in the excretion of ascorbic acid in the urine as determined by the sodium 2-6 dichlorobenzenoneindophenol method. 2. The maximum excretion of vitamin C in the urine following the oral administration of dilantin is reached on the fourth day, returning to its control level on the fifth to seventh day. 3. The body supply of vitamin C appears to be gradually decreased by the administration of dilantin as indicated by our tissue studies.