PT  - JOURNAL ARTICLE
AU  - MILES E. DRAKE
AU  - CHARLES M. GRUBER
AU  - VICTOR G. HAURY
TI  - THE EFFECTS OF SODIUM DIPHENYL HYDANTOINATE (DILANTIN) ON VITAMIN C LEVEL IN TISSUES AND VITAMIN C EXCRETION IN RATS
DP  - 1941 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 268--272
VI  - 71
IP  - 3
4099  - http://jpet.aspetjournals.org/content/71/3/268.short
4100  - http://jpet.aspetjournals.org/content/71/3/268.full
SO  - J Pharmacol Exp Ther1941 Mar 01; 71
AB  - 1. Sodium diphenyl hydantoinate (Dilantin) given orally to albino rats causes an increase in the excretion of ascorbic acid in the urine as determined by the sodium 2-6 dichlorobenzenoneindophenol method. 2. The maximum excretion of vitamin C in the urine following the oral administration of dilantin is reached on the fourth day, returning to its control level on the fifth to seventh day. 3. The body supply of vitamin C appears to be gradually decreased by the administration of dilantin as indicated by our tissue studies.