RT Journal Article
SR Electronic
T1 TOXICITY OF NAPHTHOQUINONES WITH VITAMIN K ACTIVITY IN MICE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 210
OP 214
VO 71
IS 3
A1 MICHAEL B. SHIMKIN
YR 1941
UL http://jpet.aspetjournals.org/content/71/3/210.abstract
AB The acute and chronic toxicity of six naphthoquinones with vitamin K activity were studied in mice. The compounds at high doses are respiratory depressants and produce acute vascular congestion which is sufficient to cause hemorrhagic extravasation in the renal tubules and in the liver. No weight loss, anemia, or morphologic changes were observed in mice which were injected subcutaneously with 4 to 18 mgm. of 2-methyl-1, 4-naphthoquinone during 3 to 6 weeks.