RT Journal Article
SR Electronic
T1 THE ACTION OF AMINOPYRIN AND ANTIPYRIN ON THE OXIDATION OF PHOSPHOLIPID BY VARIOUS TISSUES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 459
OP 463
VO 66
IS 4
A1 FREDERICK BERNHEIM
YR 1939
UL http://jpet.aspetjournals.org/content/66/4/459.abstract
AB 1. Aminopyrin in a concentration of M/4500 inhibits the oxygen uptake of rat liver suspensions. Six to ten times the amount of antipyrin is without effect. The inhibition is greatest at pH 6.7. 2. The vanadium catalyzed oxidation of phospholipids by liver and bone marrow which is maximal at pH 6.7 is inhibited by aminopyrin but not by antipyrin. Other tissues show smaller vanadium effects but they react similarly to the two drugs.