RT Journal Article
SR Electronic
T1 STUDIES ON THE SYNERGISM AND ANTAGONISM OF DRUGS II. THE ACTION OF PHYSOSTIGMINE ON AUTONOMIC GANGLIA
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 105
OP 110
VO 58
IS 1
A1 THEODORE KOPPANYI
A1 JAMES M. DILLE
A1 CHARLES R. LINEGAR
YR 1936
UL http://jpet.aspetjournals.org/content/58/1/105.abstract
AB The administration of physostigmine abolishes the vagal (parasympathetic) paralysis produced by nicotine or curare. The administration of physostigmine abolishes the sympathetic paralysis produced by nicotine. The ganglionic paralytic effect of nicotine and curare exerted in the autonomic system is opposed by physostigmine, but not by pilocarpine. Atropine prevents the ganglionic effect of physostigmine. An explanation is offered for this ganglionic "stimulant" effect of physostigmine.