PT - JOURNAL ARTICLE AU - THEODORE KOPPANYI AU - JAMES M. DILLE AU - CHARLES R. LINEGAR TI - STUDIES ON THE SYNERGISM AND ANTAGONISM OF DRUGS II. THE ACTION OF PHYSOSTIGMINE ON AUTONOMIC GANGLIA DP - 1936 Sep 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 105--110 VI - 58 IP - 1 4099 - http://jpet.aspetjournals.org/content/58/1/105.short 4100 - http://jpet.aspetjournals.org/content/58/1/105.full SO - J Pharmacol Exp Ther1936 Sep 01; 58 AB - The administration of physostigmine abolishes the vagal (parasympathetic) paralysis produced by nicotine or curare. The administration of physostigmine abolishes the sympathetic paralysis produced by nicotine. The ganglionic paralytic effect of nicotine and curare exerted in the autonomic system is opposed by physostigmine, but not by pilocarpine. Atropine prevents the ganglionic effect of physostigmine. An explanation is offered for this ganglionic "stimulant" effect of physostigmine.