RT Journal Article
SR Electronic
T1 THE PHARMACOLOGICAL ACTION OF CORIAMYRTIN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 410
OP 418
VO 57
IS 4
A1 SWANSON, EDWARD E.
A1 CHEN, K. K.
YR 1936
UL http://jpet.aspetjournals.org/content/57/4/410.abstract
AB 1. Coriamyrtin, C15H18O5, is a typical convulsant substance and has an action similar to picrotoxin. It is more prompt but shorter in duration than that of the latter. 2. The minimal convulsive and minimal lethal doses, as compared with those of picrotoxin, have been determined in frogs, mice, rats, and rabbits by subcutaneous or intravenous injection, or both. 3. "Sodium Amytal" can detoxify in rabbits 45 minimal fatal doses of coriamyrtin, and 40 minimal lethal doses of picrotoxin. 4. Conversely, coriamyrtin or picrotoxin can detoxify in rabbits 1¾ but not 2 minimal lethal doses of "Sodium Amytal." In monkeys, coriamyrtin abolishes anesthesia and causes awakening following a minimal anesthetic dose of "Sodium Amytal."