RT Journal Article
SR Electronic
T1 ON THE REMOVAL OF DIFFUSIBLE SUBSTANCES FROM THE CIRCULATING BLOOD OF LIVING ANIMALS BY DIALYSIS II. SOME CONSTITUENTS OF THE BLOOD
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 611
OP 623
VO 5
IS 6
A1 ABEL, JOHN J.
A1 ROWNTREE, LEONARD G.
A1 TURNER, B. B.
YR 1914
UL http://jpet.aspetjournals.org/content/5/6/611.abstract
AB 1. The non-protein constituents of the blood have been accumulated in considerable quantity by our method of vividiffusion. The total amount of non-protein nitrogen obtained in one hundred and twelve hours was about 20 grams. Other substances, especially sugar dialysed in large quantities. 2. Quantitative data are given on the rate of accumulation of different nitrogenous substances and it is shown that their relative proportions in the diffusate do not vary very greatly from those in the blood. 3. Alanine and valine have been obtained in crystalline form. Histidine and kreatinine have been shown to be present by reactions. 4. Oxyacids were found in noticeable proportion. Lactic and β-oxybutyric acids in particular have been identified. 5. In the residue from the ester-distillation there was found a crystalline substance having the composition, C7H12N2O2. In its melting point ( 210½ to 211° cor.), and solubilities it agrees with α-isobutyl hydantoin. The question whether this substance exists as such in the blood or whether it has been formed by chemical action in the process of isolation has not yet been decided.