%0 Journal Article %A CHARLES M. GRUBER %A RAYMOND HEILIGMAN %A ANTHONY DENOTE %T THE EFFECT OF METHYL-AMINO METHYL HEPTENE (OCTIN) UPON THE INTACT INTESTINE IN THE NON-ANESTHETIZED DOG %D 1936 %J Journal of Pharmacology and Experimental Therapeutics %P 284-289 %V 56 %N 3 %X 1. Octin bitartrate and octin hydrochloride when injected intravenously in a non-anesthetized dog cause loss in the general tonus, decreased force of the rhythmical contractions and decreased peristaltic activity in the Thiry-Vella loop of either the jejunum or ileum and of the duodenum. 2. Equal quantities of either octin or papaverine, when injected produced a decreased tonus but the duration of the effect of the former drug is found to be three to twelve times longer than that of the latter. 3. Octin bitartrate in large doses caused nausea and vomiting in some of the animals studied. 4. Octin causes a temporary fall followed by a prolonged rise in blood pressure. 5. The cardiac stimulating action of octin is similar to that of epinephrine but larger doses are needed. 6. The excised uterus of the rabbit is contracted by octin. The uterus of the non-pregnant cat which is relaxed by adrenalin is contracted by octin. 7. Octin causes slight vaso-constriction of the blood vessels in frogs. 8. The relaxation of bronchial muscle observed with octin was less than that noted with adrenalin. %U https://jpet.aspetjournals.org/content/jpet/56/3/284.full.pdf