PT  - JOURNAL ARTICLE
AU  - RALPH H. CHENEY
TI  - VENTRICULAR RESPONSE IN CAFFEINE-NICOTINE ANTAGONISM
DP  - 1935 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 42--52
VI  - 54
IP  - 1
4099  - http://jpet.aspetjournals.org/content/54/1/42.short
4100  - http://jpet.aspetjournals.org/content/54/1/42.full
SO  - J Pharmacol Exp Ther1935 May 01; 54
AB  - 1. Nicotine, in the concentrations employed, affects the ventricular muscle of the frog directly by producing an increased tonus and a decreased amplitude of the contraction. 2. Caffeine, in the concentrations employed, does not affect the tonus; and, in the percentages of 0.5 per cent caffeine-in-Ringer or below, it definitely increases the amplitude of the ventricular strip contraction in the frog. 3. Complete recovery of the normal ventricular strip behavior occurs regularly after treatment by either 0.2 per cent caffeine-in-Ringer, or 0.2 per cent nicotine-in-Ringer. 4. Definite antagonism occurs between caffeine and nicotine in their separate physiological effects upon the ventricular muscle of the frog. Under the conditions of the experimental series reported here, the neutralization proportionality for 0.2 per cent RN vs. 0.2 per cent RC was 15 cc. RN:85 per cent RC.