PT  - JOURNAL ARTICLE
AU  - JONES, HERMAN D.
AU  - HUGHES, R. C.
AU  - JOHNSTON, G. BERNARD
TI  - A STUDY OF THE EFFECTS OF AGAVE CONCENTRATE IN THE TREATMENT OF EXPERIMENTAL NEPHRITIS INDUCED IN ANIMALS II. NEPHRITIS INDUCED IN DOGS BY THE USE OF URANIUM NITRATE
DP  - 1933 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 25--49
VI  - 48
IP  - 1
4099  - http://jpet.aspetjournals.org/content/48/1/25.short
4100  - http://jpet.aspetjournals.org/content/48/1/25.full
SO  - J Pharmacol Exp Ther1933 May 01; 48
AB  - 1. A uniformly acute uranium nephritis was produced. 2. Seven of the 10 control animals of group I died, giving a 70 per cent mortality. 3. Five of the 16 animals which received both the uranium nitrate and the agave concentrate in group I died, giving a 31 per cent mortality. 4. The functional changes of all control animals and the kidney pathology are in close agreement with those of MacNider (6). 5. The functional changes and the pathology of those animals receiving both the uranium nitrate and the agave concentrate showed a marked improvement over those of the control animals. 6. There was not a sufficient renal disturbance developed in animals of group II for the results to be significant. From these observations the agave concentrate apparently had a protective action on the kidney or aided materially in eliminating the uranium nitrate in a very short time, thus preventing its corrosive action on that organ.