PT  - JOURNAL ARTICLE
AU  - MERL E. FISK
AU  - FRANK P. UNDERHILL
TI  - A BRIEF STUDY OF THE ANESTHETIC ACTION OF A SERIES OF NAPHTHALENE DERIVATIVES
DP  - 1933 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 329--336
VI  - 49
IP  - 3
4099  - http://jpet.aspetjournals.org/content/49/3/329.short
4100  - http://jpet.aspetjournals.org/content/49/3/329.full
SO  - J Pharmacol Exp Ther1933 Nov 01; 49
AB  - A pharmacological study of the anesthetic properties of a series of naphthalene derivatives has been made. All of the members of this series possess the power of producing anesthesia when applied to frog's skin, to the rabbit's cornea or directly to nerve trunks. On the whole, they are readily absorbed and act rapidly, but they are markedly irritant and are further unfitted for clinical use by their instability in solution. However, one member of the series, no. 133 (2-ethoxy-3-diethylaminopropylnaphthoate), is superior to the others, being rapidly absorbed, only slightly irritant, stable in solution, and of good anesthetic power.