TY - JOUR T1 - CARBAZOL DERIVATIVES I. LOCAL ANESTHETICS OF URETHANE TYPE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 69 LP - 78 VL - 47 IS - 1 AU - P. K. KNOEFEL Y1 - 1933/01/01 UR - http://jpet.aspetjournals.org/content/47/1/69.abstract N2 - Substituted aminoalkyl esters of carbazol-N-carboxylic acid have high local anesthetic activity, and in general, low toxicity. The presence of a urethane linkage appears to reduce the stimulant effect on the central nervous system that most local anesthetics possess, and to contribute a primary depressant effect. The most promising compound of the series (diethylaminoethyl carbazol-N-carboxylate, Carbacaine) has pressor activity, is absorbed slowly from subcutaneous tissues, and is detoxified more rapidly than cocaine. The use of the citrate as a soluble salt of carbacaine base, rather than the hydrochloride reduces the local irritation and confers stability. ER -