PT  - JOURNAL ARTICLE
AU  - J. A. GUNN
TI  - THE CONGENITAL TOLERANCE OF THE RAT TO STROPHANTHUS
DP  - 1913 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 225--233
VI  - 4
IP  - 3
4099  - http://jpet.aspetjournals.org/content/4/3/225.short
4100  - http://jpet.aspetjournals.org/content/4/3/225.full
SO  - J Pharmacol Exp Ther1913 Jan 01; 4
AB  - 1. The minimum lethal dose by subcutaneous injection of an extract of strophanthus was found to be thirty times greater for the rat than for the rabbit. 2. A solution of this extract, twenty to forty times stronger, is required to arrest the isolated rat's heart than suffices to arrest the isolated rabbit's heart in the same time. 3. The congenital tolerance of the rat to strophanthus can therefore be explained by the fact that the rat's heart itself is insusceptible to the action of strophanthus. 4. The tolerance of the toad's heart to digitalis-like poisons may be unconnected with the fact that the toad secretes a posion which has a similar cardiac action.