PT  - JOURNAL ARTICLE
AU  - B. B. RAGINSKY
AU  - WESLEY BOURNE
AU  - MAURICE BRUGER
TI  - THE EFFECT OF AVERTIN UPON THE CIRCULATION
DP  - 1931 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 219--231
VI  - 43
IP  - 1
4099  - http://jpet.aspetjournals.org/content/43/1/219.short
4100  - http://jpet.aspetjournals.org/content/43/1/219.full
SO  - J Pharmacol Exp Ther1931 Sep 01; 43
AB  - 1. Avertin fluid, avertin crystals, and amylene hydrate, in concentrations much higher than are found in normal avertin anesthesia in man, produce no deleterious effects upon the heart. 2. In much greater concentrations these drugs slow the heart, diminish the peripheral putput and increase the coronary circulation. 3. Adrenaline in avertin anesthesia frequently produces cardiac irregularity and in heart-lung preparations occasionally causes ventricular fibrillation. 4. Experiments using a mechanical heart indicate that the peripheral circulation as well as the heart is affected by avertin. The importance of this action is rather difficult to evaluate, but it appears to be of comparatively little importance.