TY - JOUR T1 - THE USE OF SODIUM AMYTAL IN THE PRODUCTION OF ANESTHESIA IN THE RAT JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 125 LP - 129 VL - 46 IS - 1 AU - J. S. NICHOLAS AU - D. H. BARRON Y1 - 1932/09/01 UR - http://jpet.aspetjournals.org/content/46/1/125.abstract N2 - 1. Sodium amytal (Lilly) affords a safe and convenient method for the routine production of anesthesia in the rat. 2. There is a marked difference in the amount of the substance which can be safely employed in males and females. The female dosage is just one-half the male dosage. Immature rats require the lower dosage. 3. The efficiency of the drug is lessened by dilution. The more concentrated solutions produce more uniform results with the actual use of less amytal. 4. In the rat, the only contraindication to the use of sodium amytal so far found is a chronic respiratory infection. 5. Death in cases of overdosage is generally due to respiratory failure. ER -