RT Journal Article
SR Electronic
T1 SOME OBSERVATIONS ON THE EFFECT OF PITRESSIN UPON THE CARDIOVASCULAR SYSTEM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 435
OP 447
VO 39
IS 4
A1 CHARLES M. GRUBER
A1 WILLIAM B. KOUNTZ
YR 1930
UL http://jpet.aspetjournals.org/content/39/4/435.abstract
AB 1. Pitressin in both acid and alkaline solutions produces vasoconstriction of the coronary vessels in excised perfused isolated hearts of rabbits (confirmatory of Anrep). Pitocin similarly injected caused coronary vaso-dilatation. 2. The peripheral vessels of frogs are always constricted by pitressin in alkaline solution, but usually dilated when the acid solution is used. This latter action, we believe, is due to the acidity of the fluid injected. 3. Aqueous extracts of pure pituitary powder causes an increase in the volume of the heart (confirmation of Kolls and Geiling, and Bodo). 4. Pitressin produces an increase in the volume of the dog's heart when injected intravenously. 5. A second injection of either pitressin or pituitary extract subsequent to the first injection did not influence cardiac volume. 6. In our experiments pitocin did not influence cardiac volume when injected intravenously.