TY - JOUR T1 - SOME OBSERVATIONS ON THE EFFECT OF PITRESSIN UPON THE CARDIOVASCULAR SYSTEM JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 435 LP - 447 VL - 39 IS - 4 AU - CHARLES M. GRUBER AU - WILLIAM B. KOUNTZ Y1 - 1930/08/01 UR - http://jpet.aspetjournals.org/content/39/4/435.abstract N2 - 1. Pitressin in both acid and alkaline solutions produces vasoconstriction of the coronary vessels in excised perfused isolated hearts of rabbits (confirmatory of Anrep). Pitocin similarly injected caused coronary vaso-dilatation. 2. The peripheral vessels of frogs are always constricted by pitressin in alkaline solution, but usually dilated when the acid solution is used. This latter action, we believe, is due to the acidity of the fluid injected. 3. Aqueous extracts of pure pituitary powder causes an increase in the volume of the heart (confirmation of Kolls and Geiling, and Bodo). 4. Pitressin produces an increase in the volume of the dog's heart when injected intravenously. 5. A second injection of either pitressin or pituitary extract subsequent to the first injection did not influence cardiac volume. 6. In our experiments pitocin did not influence cardiac volume when injected intravenously. ER -