RT Journal Article
SR Electronic
T1 THE EFFECT OF AMMONIUM CHLORIDE ON THE DEVELOPMENT OF RIGIDITY IN EXPERIMENTAL LOCAL TETANUS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 51
OP 55
VO 38
IS 1
A1 H. H. DIXON
A1 S. W. RANSON
YR 1930
UL http://jpet.aspetjournals.org/content/38/1/51.abstract
AB Large doses of ammonium chloride relieve the rigidity of the extensor muscles caused by tetanus toxin in white rats and prevent the development of contracture or general tetanus if the dose of toxin has been a moderate one. Whether this beneficial effect is due to acidosis or to a specific action of the ammonium radical was not determined but other substances that cause acidosis were without effect as was also ammonium acetate. The progress of the experimental tetanus was not affected by such alterations of the serum calcium as could be produced by the administration of fairly large doses of sodium fluoride, neutral sodium phosphate, or calcium chloride.