RT Journal Article
SR Electronic
T1 A View on Imaging in Drug Research and Development for Respiratory Diseases
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 335
OP 349
DO 10.1124/jpet.110.172635
VO 337
IS 2
A1 Cees J. A. van Echteld
A1 Nicolau Beckmann
YR 2011
UL http://jpet.aspetjournals.org/content/337/2/335.abstract
AB With the incidence of respiratory diseases increasing throughout the world, new therapies are needed. This review provides a short overview of different imaging techniques of interest for drug discovery and development within the pulmonary disease area. The focus is on studies performed in both animals and humans, which are of importance for understanding pathophysiological aspects and evaluating new drugs. Rather than emphasizing particular lung diseases, the noninvasive diagnosis and quantification of a number of characteristics related to several pathological conditions of the lung are addressed: inflammation, mucus secretion and clearance, emphysema, ventilation, perfusion, fibrosis, airway remodeling, and pulmonary arterial hypertension. Techniques are discussed based on their present use or potential future utilization in the context of drug studies.