RT Journal Article
SR Electronic
T1 Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 210
OP 219
DO 10.1124/jpet.109.154955
VO 332
IS 1
A1 Chiara Cervetto
A1 Guido Maura
A1 Manuela Marcoli
YR 2010
UL http://jpet.aspetjournals.org/content/332/1/210.abstract
AB We found that both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.© 2010 by The American Society for Pharmacology and Experimental Therapeutics