PT  - JOURNAL ARTICLE
AU  - Chiara Cervetto
AU  - Guido Maura
AU  - Manuela Marcoli
TI  - Inhibition of Presynaptic Release-Facilitatory Kainate Autoreceptors by Extracellular Cyclic GMP
AID  - 10.1124/jpet.109.154955
DP  - 2010 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 210--219
VI  - 332
IP  - 1
4099  - http://jpet.aspetjournals.org/content/332/1/210.short
4100  - http://jpet.aspetjournals.org/content/332/1/210.full
SO  - J Pharmacol Exp Ther2010 Jan 01; 332
AB  - We found that both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate autoreceptors were present on the glutamate-releasing terminals of cerebellar parallel/climbing fibers and that they functioned as facilitatory autoreceptors. Extracellular cGMP inhibited the neurotransmitter release evoked by presynaptic kainate receptor activation; the inhibitory effect of extracellular cGMP was selective for the kainate autoreceptor-mediated response and did not affect the AMPA autoreceptor-mediated response. Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation.© 2010 by The American Society for Pharmacology and Experimental Therapeutics