PT  - JOURNAL ARTICLE
AU  - J. E. THOMAS
TI  - A COMPARATIVE STUDY OF THE CONVULSANT ACTION OF THE ACID AND NEUTRAL SALTS OF ACID FUCHSIN
DP  - 1928 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1--19
VI  - 33
IP  - 1
4099  - http://jpet.aspetjournals.org/content/33/1/1.short
4100  - http://jpet.aspetjournals.org/content/33/1/1.full
SO  - J Pharmacol Exp Ther1928 May 01; 33
AB  - 1. Acid solutions of red, acid fuchsin cause convulsions, in frogs, in less time and with greater regularity than decolorized, alkaline solutions, provided the dye is administered by injection into the bloodless aorta or perfused through the blood vessels. 2. Alkaline solutions of fuchsin, when perfused through the vascular system cause convulsions in less time shortly after the dye is added to the solution, and before it has become decolorized, than the same solutions after they become colorless, i.e., after the red, acid salts have been entirely replaced by the colorless neutral salts. 3. The conclusion is drawn that the red, acid salts of acid fuchsin have more of a convulsant action on frogs than do the colorless, neutral salts. The difference in physiological action is believed to result from chemical changes associated with the change in color. 4. Most of the anomalous physiological properties of acid fuchsin can be explained on the basis of this conclusion.