RT Journal Article
SR Electronic
T1 Role of Matrix Metalloproteinases in Intestinal Inflammation
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 933
OP 938
DO 10.1124/jpet.106.103465
VO 318
IS 3
A1 Carlos Medina
A1 Marek W. Radomski
YR 2006
UL http://jpet.aspetjournals.org/content/318/3/933.abstract
AB Matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), are produced in the gastrointestinal tract by several structural cells. The balance between MMPs and TIMPs is essential for many physiological processes in the gut. However, imbalance between MMPs and TIMPs plays an important role in the pathophysiology of diverse intestinal inflammatory conditions. We reviewed the role of the MMP/TIMP system in the pathogenesis of intestinal inflammatory diseases and pharmacologic perspectives for the use of compounds that restore the MMP/TIMP balance. The American Society for Pharmacology and Experimental Therapeutics