RT Journal Article
SR Electronic
T1 Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1
OP 6
DO 10.1124/jpet.301.1.1
VO 301
IS 1
A1 Ursula Sonnewald
A1 Hong Qu
A1 Michael Aschner
YR 2002
UL http://jpet.aspetjournals.org/content/301/1/1.abstract
AB The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1) the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2) the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3) the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4) the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental. The American Society for Pharmacology and Experimental Therapeutics