@article {Sonnewald1, author = {Ursula Sonnewald and Hong Qu and Michael Aschner}, title = {Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling}, volume = {301}, number = {1}, pages = {1--6}, year = {2002}, doi = {10.1124/jpet.301.1.1}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The interaction between astrocytes and neurons is examined from the standpoint of glutamate neurotoxicity. The review details 1) the distribution of glutamate transporters on astrocytes and neurons, provoking a reformulation of the interdependence between these two cell types in removing extracellular glutamate and preventing excitotoxic injury; 2) the potential involvement of aberrant glutamate transporter function in the etiology of neuropathological conditions; 3) the role of astrocyte-neuron interaction in widely divergent aspects of brain energetics; 4) the role of astrocytes in the process of glutamate recycling within the context of anesthetic treatment with pentobarbital and thiopental. The American Society for Pharmacology and Experimental Therapeutics}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/301/1/1}, eprint = {https://jpet.aspetjournals.org/content/301/1/1.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }