TY - JOUR T1 - Effects of Dopamine Receptor Blockade on Cerebral Blood Flow Response to Somatosensory Stimulation in the Unanesthetized Rat JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 497 LP - 502 DO - 10.1124/jpet.102.039081 VL - 303 IS - 2 AU - Takanori Esaki AU - Yoshiaki Itoh AU - Kazuaki Shimoji AU - Michelle Cook AU - Jane Jehle AU - Louis Sokoloff Y1 - 2002/11/01 UR - http://jpet.aspetjournals.org/content/303/2/497.abstract N2 - Local cerebral blood flow (CBF) was determined in 30 cerebral structures, including four structures of the whisker-to-barrel cortex sensory pathway, by the quantitative autoradiographic [14C]iodoantipyrine method during unilateral vibrissal stimulation in rats administered 0.1 or 1.0 mg/kg haloperidol or its control vehicle intravenously. The low dose of haloperidol had no significant effects on resting CBF or its enhancement by vibrissal stimulation. By standard t tests, the high dose statistically significantly lowered baseline CBF in frontal and visual cortex, hippocampus, dentate gyrus, inferior olive, cerebellar cortex, and the ventral posteromedial (VPM) thalamic nucleus on the unstimulated side, and raised baseline CBF in the lateral habenula; however, these changes lost statistical significance after Bonferroni correction for multiple comparisons. Neither dose had any effects on the increases in CBF evoked by vibrissal stimulation in the principal sensory trigeminal nucleus and barrel cortex, but the higher dose statistically significantly enhanced the percent increases in CBF due to the sensory stimulation in the spinal trigeminal nucleus and VPM thalamic nucleus. These results do not support a role for direct dopaminergic vasoactive mechanisms in the increases in CBF associated with neuronal functional activation. U.S. Government ER -