PT  - JOURNAL ARTICLE
AU  - Jae Moon Choi
AU  - Hwa Kyoung Shin
AU  - Ki Young Kim
AU  - Jeong Hyun Lee
AU  - Ki Whan Hong
TI  - Neuroprotective Effect of Cilostazol against Focal Cerebral Ischemia via Antiapoptotic Action in Rats
AID  - 10.1124/jpet.300.3.787
DP  - 2002 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 787--793
VI  - 300
IP  - 3
4099  - http://jpet.aspetjournals.org/content/300/3/787.short
4100  - http://jpet.aspetjournals.org/content/300/3/787.full
SO  - J Pharmacol Exp Ther2002 Mar 01; 300
AB  - This study examined the protective effects of cilostazol on cerebral infarcts produced by subjecting rats to 2-h occlusion of the left middle cerebral artery followed by 24-h reperfusion. The ischemic cerebral infarct consistently involved the cortex and striatum. The infarct size was significantly reduced, when rats received 10 mg/kg cilostazol intravenously 5 min or 1 h after the completion of 2-h ischemia. Cyclic AMP level was significantly elevated in the cortex of 4- and 12-h reperfusion (P < 0.01) following treatment with cilostazol (10 mg/kg, 5 min after 2-h ischemia) accompanied by decreased tumor necrosis factor-α level. Samples from the regions corresponding to the penumbra showed markedly reduced Bcl-2 protein level and, in contrast, high levels of Bax protein and cytochrome c release. Cilostazol decreased Bax protein and cytochrome c release and increased the levels of Bcl-2 protein. Cilostazol (10−7–10−5 M) potently and concentration dependently scavenged hydroxyl and peroxyl radicals. In conclusion, cilostazol treatment decreases ischemic brain infarction in association with inhibition of apoptotic and oxidative cell death. The American Society for Pharmacology and Experimental Therapeutics