RT Journal Article
SR Electronic
T1 Geraniol, a Component of Plant Essential Oils, Inhibits Growth and Polyamine Biosynthesis in Human Colon Cancer Cells
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 197
OP 200
VO 298
IS 1
A1 Carnesecchi, S.
A1 Schneider, Y.
A1 Ceraline, J.
A1 Duranton, B.
A1 Gosse, F.
A1 Seiler, N.
A1 Raul, F.
YR 2001
UL http://jpet.aspetjournals.org/content/298/1/197.abstract
AB Geraniol and other monoterpenes found in essential oils of fruits and herbs have been suggested to represent a new class of agents for cancer chemoprevention. As a first step in clarifying the mode of action of geraniol on colon carcinogenesis, we studied its effects on the growth of a human colon cancer cell line (Caco-2). Geraniol (400 μM) caused a 70% inhibition of cell growth, with cells accumulating in the S transition phase of the cell cycle, and concomitant inhibition of DNA synthesis. No signs of cytotoxicity or apoptosis were detected. Geraniol caused a 50% decrease of ornithine decarboxylase activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth. This led to a 40% reduction of the intracellular pool of putrescine. Geraniol also activated the intracellular catabolism of polyamines, indicated by enhanced polyamine acetylation. These observations indicate that polyamine metabolism is presumably a target in the antiproliferative properties of geraniol. The American Society for Pharmacology and Experimental Therapeutics