RT Journal Article
SR Electronic
T1 Sex- and Estrous Cycle-Related Differences in the Effects of Acute Antipsychotic Drug Administration on Neurotensin-Containing Neurons in the Rat Brain
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 205
OP 211
VO 295
IS 1
A1 Becky Kinkead
A1 Steven M. Lorch
A1 Michael J. Owens
A1 Charles B. Nemeroff
YR 2000
UL http://jpet.aspetjournals.org/content/295/1/205.abstract
AB The effects of a single injection of haloperidol (2.0 mg/kg), a typical antipsychotic drug, on neurotensin (NT) concentrations and NT/neuromedin N (NT/NN) mRNA expression in adult female and male rats were examined. There were significant estrous cycle stage-related differences in both NT concentrations and NT/NN mRNA expression in female control rats. Although acute administration of haloperidol increased NT concentrations and NT/NN mRNA expression in the caudate/putamen and nucleus accumbens of both male and female rats, haloperidol did not increase NT/NN mRNA expression during diestrus 2 or NT concentrations during proestrus in the nucleus accumbens of female rats. These results indicate the presence of both sex- and estrous cycle-related differences in the regulation of NT-containing neurons and in the effects of antipsychotic drug administration on the NT system of the rat brain. The American Society for Pharmacology and Experimental Therapeutics