RT Journal Article
SR Electronic
T1 Review of Mammalian DNA Repair and Translational Implications
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1
OP 9
VO 295
IS 1
A1 Hansen, W. Kent
A1 Kelley, Mark R.
YR 2000
UL http://jpet.aspetjournals.org/content/295/1/1.abstract
AB The area of mammalian DNA repair and its relationship to cancer and therapeutic approaches is rapidly growing, both through the studies of basic mechanisms and in the use of this knowledge for translational applications. We have attempted to briefly and succinctly cover the four pathways of mammalian DNA repair, which are: direct reversal, mismatch, nucleotide excision, and base excision repair. We have also tried to identify and reference results in the literature relating the various repair pathways to cellular resistance following chemotherapeutic treatments and to provide some potential direction whereby laboratory results may be applicable to clinical therapeutics, particularly for cancer treatments. The American Society for Pharmacology and Experimental Therapeutics