RT Journal Article
SR Electronic
T1 Combinatorial Chemistry and Contemporary Pharmacology
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 705
OP 709
VO 293
IS 3
A1 Lazo, John S.
A1 Wipf, Peter
YR 2000
UL http://jpet.aspetjournals.org/content/293/3/705.abstract
AB Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high-throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development. The American Society for Pharmacology and Experimental Therapeutics