PT  - JOURNAL ARTICLE
AU  - John S. Lazo
AU  - Peter Wipf
TI  - Combinatorial Chemistry and Contemporary Pharmacology
DP  - 2000 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 705--709
VI  - 293
IP  - 3
4099  - http://jpet.aspetjournals.org/content/293/3/705.short
4100  - http://jpet.aspetjournals.org/content/293/3/705.full
SO  - J Pharmacol Exp Ther2000 Jun 01; 293
AB  - Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high-throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development. The American Society for Pharmacology and Experimental Therapeutics