RT Journal Article SR Electronic T1 Phospholipase A2s in Cell Injury and Death JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 793 OP 799 VO 294 IS 3 A1 Brian S. Cummings A1 Jane McHowat A1 Rick G. Schnellmann YR 2000 UL http://jpet.aspetjournals.org/content/294/3/793.abstract AB Phospholipase A2s (PLA2s) represent a family of esterases that hydrolyze the sn-2 ester bond in phospholipids, releasing free fatty acids and lysophospholipids. PLA2s are important in the signaling of several cellular processes and are known to play a significant role in inflammation. Studies also show that PLA2s are modulators of drug-, chemical-, and ischemia/reperfusion-induced cellular injury. The role of PLA2s in apoptosis and oncosis depends upon the PLA2 isoform, the cell type, and the stimulus of injury. The purpose of this review is to discuss the functions of iPLA2, cPLA2 and sPLA2 isoforms in oncosis and apoptosis, including oxidant-induced and receptor-mediated cell death. In addition, the measurement and modulation of PLA2 is discussed. The American Society for Pharmacology and Experimental Therapeutics