PT - JOURNAL ARTICLE AU - Diego Gonzalez-Ramirez AU - Miguel Zuniga-Charles AU - Antonio Narro-Juarez AU - Yolanda Molina-Recio AU - Katherine M. Hurlbut AU - Richard C. Dart AU - H. Vasken Aposhian TI - DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride DP - 1998 Oct 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 8--12 VI - 287 IP - 1 4099 - http://jpet.aspetjournals.org/content/287/1/8.short 4100 - http://jpet.aspetjournals.org/content/287/1/8.full SO - J Pharmacol Exp Ther1998 Oct 01; 287 AB - DMPS (2,3-dimercaptopropane-1-sulfonate, Na salt), when used as a challenge test for mercury in workers involved in the production of a calomel skin-bleaching lotion and in direct contact with mercurous chloride, elevated urine levels of mercury. A DMPS treatment regimen was devised and initiated. Three days after the challenge test, DMPS was administered p.o. (400 mg per day) for 8 days, followed by a no-treatment period of five days. A new cycle of DMPS treatment for 7 days was initiated and followed by 5 days without treatment. A third period of treatment was begun for 6 days, followed by a 5-day no-treatment period. The urinary mercury greatly increased during those periods when DMPS was administered (1754, 314, and 173 μg/24 h for the periods 1, 2 and 3, compared with 106, 48 and 53 μg/24 h on the corresponding no-treatment periods). One of the workers presented signs of drug intolerance and was discharged after receiving the first cycle of treatment. DMPS treatment was effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels. The American Society for Pharmacology and Experimental Therapeutics