PT  - JOURNAL ARTICLE
AU  - Dong-Keun Song
AU  - Hong-Won Suh
AU  - Sung-Oh Huh
AU  - Jun-Sub Jung
AU  - Bong-Moo Ihn
AU  - Ihn-Geun Choi
AU  - Yung-Hi Kim
TI  - Central GABA<sub>A</sub> and GABA<sub>B</sub> Receptor Modulation of Basal and Stress-Induced Plasma Interleukin-6 Levels in Mice
DP  - 1998 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 144--149
VI  - 287
IP  - 1
4099  - http://jpet.aspetjournals.org/content/287/1/144.short
4100  - http://jpet.aspetjournals.org/content/287/1/144.full
SO  - J Pharmacol Exp Ther1998 Oct 01; 287
AB  - To investigate the modulatory roles of central γ-aminobutyric acid (GABA)A and GABAB receptors in the regulation of basal and stress-induced plasma interleukin-6 (IL-6) levels, we examined the effects of i.c.v. injection of GABA receptor agonists and antagonists on basal and restraint stress-induced plasma IL-6 levels in mice. Muscimol (20–200 ng), a GABAA receptor agonist, and baclofen (5–20 ng), a GABAB receptor agonist, injected i.c.v. did not affect the basal levels of plasma IL-6. In the restraint-stressed animals, muscimol and baclofen inhibited the stress-induced plasma IL-6 levels from the dose of 50 and 15 ng, respectively. 2-(3-Carboxyl)-3-amino-6-(4-methoxyphenyl)-pyridazinium bromide (SR-95,531; 0.3–10 ng), a GABAA receptor antagonist, and 2-hydroxysaclofen (1–10 μg), a GABABreceptor antagonist, injected i.c.v. increased both the basal and the restraint stress-induced plasma IL-6 levels. The i.p. pretreatment of animals with 6-hydroxydopamine (100 mg/kg) for 3 days significantly inhibited SR-95,531 (3 ng i.c.v.)- but not 2-hydroxysaclofen (10 μg i.c.v.)-induced increase in the basal plasma IL-6 levels. These data suggest that central GABAA and GABAB receptors are involved in the suppressive modulation of basal and restraint stress-induced plasma IL-6 levels in mice. The American Society for Pharmacology and Experimental Therapeutics