RT Journal Article
SR Electronic
T1 ABT-761 Attenuates Bronchoconstriction and Pulmonary Inflammation in Rodents
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1366
OP 1373
VO 280
IS 3
A1 Randy L. Bell
A1 Richard R. Harris
A1 Peter E. Malo
A1 Jennifer B. Bouska
A1 Thomas K. Shaughnessy
A1 Keren I. Hulkower
A1 Clint D. W. Brooks
A1 George W. Carter
YR 1997
UL http://jpet.aspetjournals.org/content/280/3/1366.abstract
AB Our primary goal has been to discover leukotriene biosynthesis inhibitors with characteristics that are appropriate for use as clinical agents. The success of the use of zileuton in the treatment of asthma led us to explore further the use of theN-hydroxyurea class of 5-lipoxygenase inhibitors as longer-acting compounds with good lung penetration. A variety ofin vitro and in vivo methods were used to evaluate a large number of compounds, from which ABT-761 [(R)-N-(3-(5-(4-fluorophenylmethyl)thien-2-yl)-1-methyl-2-propynyl)-N-hydroxyurea] was selected for study. ABT-761 exhibited potent and selective inhibition of leukotriene formation both in vitro andin vivo. More importantly, the compound potently inhibited antigen-induced bronchospasm in guinea pigs when given either prophylactically or therapeutically. In addition, ABT-761 was a potent inhibitor of eosinophil influx into the lungs of Brown Norway rats. These data provide added support for the role of leukotrienes in both bronchospasm and eosinophilic inflammation and characterize ABT-761 as a particularly potent inhibitor of leukotrienes formed in pulmonary tissues. These data combined with the excellent pharmacokinetic characteristics of the compound indicate its potential use in the treatment of leukotriene-dependent human disease. The American Society for Pharmacology and Experimental Therapeutics