PT  - JOURNAL ARTICLE
AU  - V. Gene Erwin
AU  - Paul D. Markel
AU  - Thomas E. Johnson
AU  - Vaughn M. Gehle
AU  - Byron C. Jones
TI  - Common Quantitative Trait Loci for Alcohol-Related Behaviors and Central Nervous System Neurotensin Measures: Hypnotic and Hypothermic Effects
DP  - 1997 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 911--918
VI  - 280
IP  - 2
4099  - http://jpet.aspetjournals.org/content/280/2/911.short
4100  - http://jpet.aspetjournals.org/content/280/2/911.full
SO  - J Pharmacol Exp Ther1997 Feb 01; 280
AB  - Genetic correlations were found between high-affinity neurotensin receptor (NTRH) densities and NT-immunoreactivity (NT-ir) levels in specific brain regions and sensitivity to hypnotic and hypothermic effects of ethanol in LSXSS recombinant inbred strains of mice. Simple sequence length polymorphisms were used to identify quantitative trait loci (QTL) influencing hypnotic and hypothermic sensitivity to ethanol, NTRH and low-affinity neurotensin receptor densities and NT-ir levels in LSXSS recombinant inbred strains. Common QTL for NTRH receptor densities, NT-ir levels and these ethanol actions were identified. One of the QTL (chromosome 2, 80 cM) for NTRH density and hypnotic sensitivity is linked to the NTRH gene, Ntsr. Also, QTL for NTRH density were found in common with confirmed QTL for hypnotic sensitivity on chromosomes 1 (43 cM), 11 (57 cM) and 15 (56 cM) and with an unconfirmed QTL on chromosome 3 (19 cM). Two common QTL for NT-ir levels, but not NTRH or low-affinity neurotensin receptor receptors, and ethanol-induced hypothermia were observed on chromosomes 4 (43 cM) and 6 (41 cM). Two common QTL for NT-ir levels and sleep time were identified on chromosomes 3 (19 cM) and 9 (55 cM). Common QTL indicate that genes regulating NT receptor and/or NT-ir expression may be the same as those regulating sensitivity to ethanol. The American Society for Pharmacology and Experimental Therapeutics