TY - JOUR T1 - THE EXCRETION OF MORPHIN INTO THE STOMACH JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 49 LP - 60 VL - 26 IS - 1 AU - ROBERT A. HATCHER AU - DAVID DAVIS Y1 - 1925/08/01 UR - http://jpet.aspetjournals.org/content/26/1/49.abstract N2 - The commonly accepted view that important amounts of morphin are excreted into the stomach rests solely on the testimony of Alt, which is not supported by any evidence that we have been able to discover; on the contrary, a study of the literature shows that careful investigators have uniformly failed to substantiate Alt's contention. We have found that only traces of morphin are excreted into the stomach of the cat and dog after the subcutaneous, intramuscular, or intravenous injection of amounts varying from 56 mgm. (75 mgm. of the sulphate) to 982 mgm. (1229 of the sulphate). If gastric lavage is of value in the treatment of morphin poisoning in these animals, this value does not depend upon the removal of morphin from the stomach. It is self-evident that the removal of even important amounts of morphin from the stomach could not cause immediate improvement, such as Alt reported. ER -