RT Journal Article
SR Electronic
T1 Basement membrane biosynthesis as a target to tumor therapy.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 753
OP 757
VO 252
IS 2
A1 Maragoudakis, M E
A1 Missirlis, E
A1 Sarmonika, M
A1 Panoutsacopoulou, M
A1 Karakiulakis, G
YR 1990
UL http://jpet.aspetjournals.org/content/252/2/753.abstract
AB Tricyclodecan-9-yl-xanthate (D609) was identified as an agent that caused selective killing of tumor cells by an unknown mechanism of action. We report an inhibition by D609 of basement membrane collagen biosynthesis in the chick chorioallantoic membrane system in vitro. In the same system in vivo D609 inhibits angiogenesis. Also treatment of rats bearing Walker 256 carcinoma with D609 results in a dose-dependent antitumor effect. These results indicate that basement membrane synthesis may be a target for developing anti-angiogenic compounds with antitumor properties.