PT  - JOURNAL ARTICLE
AU  - Maragoudakis, M E
AU  - Missirlis, E
AU  - Sarmonika, M
AU  - Panoutsacopoulou, M
AU  - Karakiulakis, G
TI  - Basement membrane biosynthesis as a target to tumor therapy.
DP  - 1990 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 753--757
VI  - 252
IP  - 2
4099  - http://jpet.aspetjournals.org/content/252/2/753.short
4100  - http://jpet.aspetjournals.org/content/252/2/753.full
SO  - J Pharmacol Exp Ther1990 Feb 01; 252
AB  - Tricyclodecan-9-yl-xanthate (D609) was identified as an agent that caused selective killing of tumor cells by an unknown mechanism of action. We report an inhibition by D609 of basement membrane collagen biosynthesis in the chick chorioallantoic membrane system in vitro. In the same system in vivo D609 inhibits angiogenesis. Also treatment of rats bearing Walker 256 carcinoma with D609 results in a dose-dependent antitumor effect. These results indicate that basement membrane synthesis may be a target for developing anti-angiogenic compounds with antitumor properties.